· In the News
· Pasteur web site
· UMR 3528 (CNRS)
· Older DSM web site
· Newer DSM web site
- Web Servers
· NOMAD-Ref server
· MAP_trajec server
· AquaSol server
· AquaSAXS server
· Job queue status
· All Papers (PDF)
· Papers by theme (2006-2016)
· Older papers (1989-2009)
· Google Scholar
· Picture of the Lab
We are part of the Department of Structural Biology and Chemistry in Institut Pasteur, Paris.
We use experimental techniques such as crystallography and cryo-electron microscopy to visualize at the atomic level the structure of molecules essential to life and to understand their functional properties, especially for
We complement them with computational approaches such as molecular dynamics (atomic models), normal modes dynamics (coarse-grained models) and statistical thermodynamics, in order to go beyond the essentially static pictures given by these methods.
Homology modelling and molecular phylogeny techniques are routinely used to extend the scope of our studies,
Here we give a selection of recent articles on ligand-gated ion channels structure and function.
Publications by year for ligand-gated ion channels (2009-2021)
Playing around with Alphafold (coming soon)
Transforming an allosteric site into an orthosteric site (or a modulator into an agonist): coming soon
Re-refinement of the closed form of GLIC up to 4.0 Angstrom, by Pierre Legrand.
A new kind of supra-molecular organisation
New allosteric sites
Pentameric Ligand-gated ion channels (pentaLGICs): drug binding sites in different conformational states
-X-ray structures of GLIC bound to Xenon, in the open and locally-closed states, with N. Colloc'h (PLoS One).
-X-ray structures of GLIC bound to Bromoform, supplemented by Molecular Dynamics studies by M. Baaden and coll. (Structure).
-Structure of a functional GLIC-GlyR chimera with P.-J. Corringer (PNAS, Feb 2015)
-Structural basis for the gating mechanism in GLIC (PNAS, Jan 2014), see Recomm by F1000
-A structural perspective in the pharmacology of pLGICs - a review (BBA, May 2014)
-Structural basis for ion permeation in GLIC (EMBO Journal, Jan 2013) at 2.4 Angstrom
-A review on cys-loop receptors with P.J. Corringer in Structure
-Atomic structure of a complex between general anesthetics with GLIC is published in Nature in 2011, Recommended by F1000
-Atomic structure of the extra-cellular (water-soluble) domain of GLIC, a pentameric ligand-gated ion-channel at high resolution in J. Mol. Biol.